Ubiquitination is a post-translational modification essential for the regulation of eukaryotic proteins, having an impact on protein fate, function, localization or activity. What originally appeared to be a simple system to regulate protein turnover by the 265 proteasome is now known to be the most intricate regulatory process cells have evolved.
Ubiquitin can be arranged in countless chain assemblies, and here I will present our work deconstructing lysine(K)63-linked polyubiquitin chains using plants as model and highlighting its major contribution in the control of plasma membrane protein dynamics.
Comprendre le fonctionnement des organismes vivants, telle est l’ambition du Centre de biologie intégrative (CBI), à Toulouse. Pour atteindre cet objectif, le CBI développe des approches multidisciplinaires, multi-échelles des molécules isolées aux organismes entiers et aux sociétés animales, et utilise de nombreux organismes modèles, des bactéries à l'homme.
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