Séminaire externe Stoyan Ivanov "CD226+ adipose tissue macrophages arise from MDP-derived monocytes and regulate lipid metabolism"

16 May 2025 11 h 00 min - 12 h 00 min

I obtained my PhD degree (summa cum laude) from the University of Lille 2 in December 2011. I worked under the supervision of Dr. François Trottein in the Center of Infection and Immunity in Lille (CIIL). For my post-doctoral training, I joined the laboratory of Dr. Gwendalyn Randolph (Washington University in Saint Louis, USA). Dr. Randolph’s laboratory has a broad and internationally recognized expertise in the field of myeloid cell regulation (migration of monocytes and DCs, macrophage biology) and the lymphatic system biology. In this dynamic environment, I started developing an independent line of research and initiated projects focused on the interaction between adipose tissue and immune cells and the role of ambient temperature on atherosclerosis development. In 2015, I joined the laboratory led by Dr. Laurent Yvan-Charvet in Nice (C3M, INSERM). I continued working on the interaction between immune cells and adipose tissue and also developed an expertise in the field of immunometabolism. In 2022, I decided to join the LP2M (UMR7370, Nice) and created a team focused on the role of immune cell metabolism during chronic and acute inflammatory diseases. We are currently investigating the diversity and functions of adipose tissue macrophages.

5 Major Publications:
1. Ivanov S et al., (2016) Regulation of lymphatic vessel permeability and transport by IRF4-dependent CCR7+ dendritic cells. J Clin Invest. 2016 Apr 1;126(4):1581-91.
2. Williams JW*, Elvington AF*, Ivanov S* et al., (2017) Thermoneutrality but not UCP1 Deficiency Suppresses Monocyte Mobilization into Blood. Circ Res. 2017 Sep 1;121(6) :662-676.
3. Gallerand A et al., (2021) Brown adipose tissue monocytes support tissue expansion. Nat Commun. Nat Commun. 2021 Sep 6;12(1):5255.
4. Dolfi B et al., 2022) Unravelling the sex-specific diversity and functions of adrenal gland macrophages. Cell Rep. 2022 Jun 14;39(11):110949. doi: 10.1016/j.celrep.2022.110949.
5. Gallerand A et al., (2024) Glucose metabolism controls monocyte homeostasis and migration but has no impact on atherosclerosis development in mice. Nat Commun. 2024 Oct 19;15(1):9027. doi: 10.1038/s41467-024-53267-5.